可溶性细胞间粘附分子-1在类风湿关节炎疾病中的应用

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目的测定类风湿关节炎(RA)患者血清中可溶性细胞间粘附分子-1(sICAM-1)的水平,探讨sICAM-1与病情的关系。方法用酶联免疫分析法(ELISA),检测30例类风湿关节炎患者与30例健康对照者血清中sICAM-1的水平。用全自动免疫速率散射比浊法测定类风湿因子(RF)和C反应蛋白(CRP)。用魏氏法测定血细胞沉降率(ESR)。结果类风湿关节炎患者血清中sICAM-1水平均高于健康对照组,各组间比较均具有显著性差异(P<0.01),sICAM-1水平与RP呈正相关(r=0.252)。结论类风湿关节炎患者血清中sICAH-1水平显著升高,sICAM-1可能参与类风湿关节炎发病过程,且类风湿关节炎病情越重sICAH-1的水平越高,sICAM-1可作为判断病情严重性的指标。 Objective To determine the level of soluble intercellular adhesion molecule-1 (sICAM-1) in patients with rheumatoid arthritis (RA) and to investigate the relationship between sICAM-1 and the disease. Methods Serum levels of sICAM-1 were measured by enzyme linked immunosorbent assay (ELISA) in 30 patients with rheumatoid arthritis and 30 healthy controls. Rheumatoid factor (RF) and C-reactive protein (CRP) were determined by automated immunostaining nephelometry. Hemocyte sedimentation rate (ESR) was measured by Weismann’s method. Results The serum levels of sICAM-1 in patients with rheumatoid arthritis were significantly higher than those in healthy controls (P <0.01). There was a positive correlation between sICAM-1 and RP (r = 0.252). Conclusions The level of sICA-1 in sera of patients with rheumatoid arthritis is significantly increased. SICAM-1 may be involved in the pathogenesis of rheumatoid arthritis. The higher the level of sICAH-1 in rheumatoid arthritis patients, the higher the level of sICAM-1 may be The severity of the disease indicators.
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