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目的:探讨沙蚕蛋白酶的抗血小板聚集作用及对血液流变学的影响。方法:利用二磷酸腺苷(ADP)、花生四烯酸及胶原诱导大鼠血小板聚集,测定血小板最大聚集率;采用股静脉注射高分子右旋糖酐建立大鼠高黏滞血症模型,检测血液流变学指标。结果:沙蚕蛋白酶可抑制诱导剂ADP,花生四烯酸及胶原引起的大鼠血小板聚集,降低其最大聚集率;可降低大鼠全血黏度,对血浆黏度、红细胞沉降率及红细胞压积均无影响。结论:沙蚕蛋白酶具有显著的血小板聚集抑制作用及改善血液流变学特性。
Objective: To investigate the anti-platelet aggregation effect of silkworm protease and its effect on hemorrheology. Methods: Platelet aggregation was induced by ADP, arachidonic acid and collagen in rats. The maximum platelet aggregation rate was determined. High molecular weight dextran was injected into the femoral vein to establish a model of hyperviscosity in rats. Blood rheology Learning indicators. Results: The silkworm protease could inhibit platelet aggregation induced by ADP, arachidonic acid and collagen in rats and reduce its maximum aggregation rate. It could reduce whole blood viscosity, plasma viscosity, erythrocyte sedimentation rate and hematocrit no effect. Conclusion: The silkworm protease has significant inhibition of platelet aggregation and hemorrheology.