尼卡地平是第二代二羟吡啶类钙离子拮抗剂,对质膜钙离子慢通道的二羟吡啶结合位点具有很强的亲和力(尼卡地平>足群地平>硝苯地平)。有关人体、动物及临床的大量实验资料表明,尼卡地平对外周及冠状动脉具有扩张作用,均能降低收缩压和舒张压;对内分泌系统,特别是对糖尿病、胰岛素释放以及催乳素、促甲状腺素、皮质醇水平等无影响;机体对尼卡地平不产生耐药性,停药后也无血压反跳现象;尼卡地平口服吸收快,主要在肝脏 Nicardipine is a second-generation calcium (II) -dihydroxypyridine antagonist with strong affinity for the dihydroxypyridine binding site of the plasma membrane calcium channel (nicardipine> riftaralpine> nifedipine). Extensive experimental data on human, animal and clinical studies indicate that nicardipine exerts a dilatation effect on the peripheral and coronary arteries, both of which reduce systolic and diastolic blood pressure; on the endocrine system, especially on diabetes, insulin release, prolactin, Hormone, cortisol level no effect; the body does not produce nicardipine resistance, no blood pressure rebound after stopping the phenomenon; nicardipine oral absorption faster, mainly in the liver