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心力衰竭是许多心脏疾病的终末阶段,这些心脏疾病包括心肌梗死、高血压、心肌病、先天性心脏病等。心力衰竭的一个显著特点是交感神经系统活性增加,循环中儿茶酚胺增多,心肌β肾上腺素受体(βARs)过度激活,信号通路发生变化。为防止心力衰竭,了解参与βARs信号通路内稳态的分子事件至关重要,现报道如下。1心肌β1AR和β2AR信号通路人类心肌含有3种βARs亚型,即β1肾上腺素受
Heart failure is the terminal stage of many heart diseases, including myocardial infarction, hypertension, cardiomyopathy, congenital heart disease and so on. A notable characteristic of heart failure is the increased activity of the sympathetic nervous system, increased circulating catecholamines, and over-activation of cardiac β-adrenergic receptors (βARs), signaling pathways. To prevent heart failure, understanding the molecular events involved in the homeostasis of the βARs signaling pathway is crucial and is reported below. 1 myocardial β1AR and β2AR signaling pathway in human myocardium contains three βARs subtypes, β1 adrenergic receptor