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目的：分析中央杏仁核（ｎｕｃｌｅｕｓａｍｙｇｄａｌｏｉｄｅｕｓｃｅｎｔｒａｌｉｓ，ＡＣ） 升压反应的中枢机制。方法：大鼠脑内注射不同药物，记录血压和心率的变化。结果：谷氨酸兴奋ＡＣ 引起的升压反应可被αＨｅｌｉｃａｌ ＣＲＦ［９４１］ （ αＨ ＣＲＦ，ＣＲＦ拮抗剂） 或［ ＤＰｒｏ２ ，ＤＰｈｅ７ ，ＤＴｒｐ９］Ｐ物质（ＤＰＤＰＤＴ，ＳＰ 拮抗剂） 分别注入双侧腹内侧核（ｎｕｃｌｅｕｓ ｖｅｎｔｒｏｍｅｄｉａｌｉｓ，ＮＶＭ） ，室旁核（ｎｕｃｌｅｕｓ ｐａｒａｖｅｎｔｒｉｃｕｌａｒｉｓ，ＮＰＶ）或延髓头端腹外侧区（ｒｏｓｔｒａｌｖｅｎｔｒｏｌａｔｅｒａｌ ｍｅｄｕｌｌａ，ＲＶＬ）衰减。结论：结合作者其他工作已证明腹内侧核升压反应是通过背内侧核作用于ＮＰＶ 和ＲＶＬ 实现的，各环节都有ＣＲＦ和ＳＰ参与，此工作结果进一步表明腹内侧核背内侧核升压机制是ＡＣ 升压反应中枢机制的一部分，ＣＲＦ和ＳＰ是该神经通路中的递质。
OBJECTIVE: To analyze the central mechanism of the step-up response in central amygdaloid alus nucleus (AC). METHODS: Different drugs were injected into the brain of rats to record the changes of blood pressure and heart rate. RESULTS: The hyperbaric response to glutamic acid-stimulated AC was demonstrated by α-Helical CRF [9-41] (α-H CRF, CRF antagonist) or [DPro2, DPhe7, DTrp9] (DPDPDT, SP antagonist) were injected into the nucleus ventromedialis (NVM), nucleus paraventricularis (NPV) or rostral ventrolateral medulla (RVL) respectively. CONCLUSIONS: In combination with other work by the authors, it has been demonstrated that the hypothalamic-ventricular hypotensive response is mediated through the dorsomedial nucleus in both NPV and RVL, and CRF and SP are involved at all stages. The results further suggest that the ventral medial dorsomedial nucleus The mechanism is part of the central mechanism of the AC boost response and CRF and SP are neurotransmitters in this pathway.