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[目的]探讨肝硬化失代偿期患者动脉血氧分压(PaO2)、氧饱和度(SaO2)和二氧化碳分压(PaCO2)的变化,评价动脉血氧在肝肺综合征(HPS)临床诊断中的价值,为诊断和预防HPS提供理论依据。[方法]应用血气分析仪测定60例肝硬化失代偿期患者(肝硬化组)及同期住院60例非肝硬化失代偿者(对照组),比较2组的PaO2、SaO2、PaCO2。并比较肝硬化组Child-Pugh为A、B、C间的PaO2、SaO2、PaCO2。[结果]肝硬化组患者低氧血症发生率为48%。①肝硬化组PaO2与对照组PaO2比较P<0.01,而肝硬化组和对照组SaO2、PaCO2值水平比较差异无统计学意义(P>0.05);②肝硬化Child-Pugh A、B、C 3级间PaO2,SaO2值比较差异有统计学意义(P<0.01),而3级间PaCO2水平比较差异无统计学意义(P>0.05),且PaO2、SaO2值随着Child-Pugh分级的增高呈下降趋势。[结论]肝硬化患者低氧血症发生率高,其发生率随着Child-Pugh分级的增高而呈梯形上升。血气分析对HPS有诊断价值。
[Objective] To investigate the changes of PaO2, SaO2 and PaCO2 in patients with decompensated liver cirrhosis and to evaluate the clinical value of arterial oxygen in the diagnosis of hepatopulmonary syndrome (HPS) In the value of diagnosis and prevention of HPS to provide a theoretical basis. [Methods] Sixty patients with decompensated cirrhosis (cirrhosis) and 60 patients with decompensated cirrhosis (control group) were enrolled in this study. PaO2, SaO2 and PaCO2 were compared between the two groups. Child-Pugh in the cirrhosis group was compared with PaO2, SaO2 and PaCO2 between A, B and C groups. [Results] The incidence of hypoxemia in patients with cirrhosis was 48%. (1) PaO2 in cirrhosis group was significantly lower than that in control group (P <0.01), while there was no significant difference in SaO2 and PaCO2 between cirrhosis group and control group (P> 0.05); (2) Child-Pugh A, B and C PaO2 and SaO2 levels were significantly different between the three groups (P <0.01), while PaCO2 levels were not significantly different among the three grades (P> 0.05), and PaO2 and SaO2 values increased with Child-Pugh classification Downtrend. [Conclusion] The incidence of hypoxemia in patients with cirrhosis is high, and its incidence increases trapezoid with the increase of Child-Pugh classification. Blood gas analysis has diagnostic value for HPS.