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目的 了解儿童结肠传输时间 (CTT)的正常值 ,并探讨促肠动力药对小儿功能性便秘 (FC)结肠传输时间的影响。方法 采用不透X线标记物测定 68例正常儿童及 2 8例FC患儿全CTT和分段结肠传输时间 ,对全CTT延长的便秘患儿 ,给予促肠动力药物西沙必利 0 2mg kg ,每日 2次 ,治疗 2周 ,停药后 1周复查CTT ,比较服药前后CTT的变化。结果 全CTT的正常值上限为 2 4h ,FC组全结肠及各节段结肠传输时间较对照组明显延长 (P <0 0 5 )。 2 8例FC患儿中 16例的全CTT延长 ,经治疗后平均全CTT由 (5 4 0 1± 3 2 3 )h缩短至 (19 63± 1 3 8)h(P <0 0 1) ,各节段结肠传输时间亦缩短。结论 不透X线标记物检查技术简单易行 ,结果可靠。促肠动力药能缩短FC患儿全结肠及各段结肠传输时间 ,可用于FC患儿
Objective To understand the normal value of colonic transit time (CTT) in children and to explore the effect of entero-propulsive drugs on the colonic transit time in children with functional constipation (FC). Methods The whole CTT and segmental colon transit time in 68 normal children and 28 children with FC were measured by radiopaque markers. The children with constipation who had prolonged CTT were given cisplatin 0 2 mg kg, 2 times a day for 2 weeks, 1 week after discontinuation of CTT review, CTT changes before and after treatment compared. Results The upper limit of normal CTT was 24 h. The colon and colon transit time in all colon and each segment of FC group was significantly longer than that in control group (P <0.05). The mean CTT of 16 cases in 28 FC patients was prolonged from (541 ± 3 2 3) h to (19 63 ± 1 38) h (P 0 01) after treatment. , All segments of the colon transmission time is also shortened. Conclusion Occult X-ray marker examination technology is simple and reliable, the results are reliable. Pacemaker can shorten the FC of children with colon and all segments of the colon transmission time can be used for FC children