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目的:观察中西医结合治疗儿童支原体肺炎(MPP)的疗效及对血清炎症因子水平的影响。方法:将110例MPP患儿随机分为观察组和对照组各55例。2组患儿均予以退热平喘、止咳化痰等基础治疗,对照组予以阿奇霉素治疗,观察组在对照组治疗基础上加用玉屏风散颗粒治疗。观察并比较2组患儿治疗前后血清白细胞介素(IL)-6、肿瘤坏死因子(TNF)-α和IL-10水平的变化,并评估临床疗效。结果:治疗后,观察组总有效率高于对照组(P<0.05)。治疗后,2组血清IL-6和TNF-α水平较治疗前下降,IL-10水平较治疗前上升,差异均有统计学意义(P<0.05,P<0.01),观察组IL-6、TNF-α下降幅度和IL-10上升幅度均较对照组更明显(P<0.05)。结论:中西医结合治疗儿童MPP疗效确切,作用机制可能与降低血清IL-6和TNF-α水平,升高血清IL-10水平,从而纠正炎症因子网络紊乱密切相关。
Objective: To observe the curative effect of Integrative Chinese and Western medicine on mycoplasma pneumoniae (MPP) in children and its effect on serum inflammatory cytokines. Methods: 110 cases of MPP were randomly divided into observation group and control group of 55 cases. Both groups were given basic treatment of antipyretic and antiasthmatic, cough and phlegm, the control group was treated with azithromycin, and the observation group was treated with Yupingfengsan Granules on the basis of the control group. The levels of serum interleukin (IL) -6, tumor necrosis factor (TNF) -α and IL-10 in the two groups before and after treatment were observed and compared. The clinical efficacy was also evaluated. Results: After treatment, the total effective rate in observation group was higher than that in control group (P <0.05). After treatment, the levels of IL-6 and TNF-α in serum in two groups decreased compared with those before treatment, and the levels of IL-10 in the two groups were significantly higher than those before treatment (P <0.05, P <0.01) The decrease of TNF-α and the increase of IL-10 were more obvious than those of the control group (P <0.05). Conclusion: Integrative Chinese medicine treatment of children with MPP exact effect, the mechanism may be related to lower levels of serum IL-6 and TNF-α, elevated serum IL-10 levels, thereby correcting inflammatory disorder network disorders.