乳腺癌是女性常见的恶性肿瘤,占女性恶性肿瘤的第1位,全世界每年约新增120万乳腺癌患者,每年新老患者中约50万人死于乳腺癌[1]。许多乳腺癌临床研究表明,乳腺癌骨转移的发生率比肺和肝这两个常见的肿瘤转移器官要高许多,表明骨是乳腺癌最常见的远处转移部位[2]。乳腺癌发生骨转移后,可导致骨质疏松、高 Breast cancer is a common malignant tumor in women, accounting for the first in female malignancies. There are about 1.2 million breast cancer patients in the world each year, and about 500,000 new and old patients die each year from breast cancer [1]. Many breast cancer clinical studies have shown that the incidence of bone metastases in breast cancer is much higher than that of the two common tumor metastases, lung and liver, indicating that bone is the most common distant metastasis of breast cancer [2]. Bone metastasis of breast cancer can lead to osteoporosis, high