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应用小剂量（２μｇ／ｋｇ）粒细胞集落刺激因子（Ｇ－ＣＳＦ）于１８例肺癌患者化疗中，以观察预防发生中性粒细胞减少症的疗效。其中小细胞肺癌５例，非小细胞肺癌１３例，随机分成Ｇ－ＣＳＦ组及对照组各９例，化疗方案为ＣＥ（卡铂－ＶＰ１６）。结果Ｇ－ＣＳＦ组粒细胞绝对计数（ＡＮＣ）＜２．０×１０９／Ｌ，发生例数５例，持续天数为３．６±３．５天；对照组持续天数１６．８±７．１天，Ｐ＜０．０５。ＡＮＣ最低值至恢复正常（ＡＮＣ＞２．０×１０９／Ｌ）的天数Ｇ－ＣＳＦ组及对照组分别为２．６±１．３天，８．９±５．３天（Ｐ＜０．０５）。Ｇ－ＣＳＦ组化疗后的第２０天ＡＮＣ均已恢复正常，ＡＮＣ为（９．７±６．８）×１０９／Ｌ故可在第２２天顺利接受第二周期化疗。对照组ＡＮＣ（１．６６±０．８）×１０９／Ｌ（Ｐ＜０．０１）。由此可见，小剂量Ｇ－ＣＳＦ能有效地防治肺癌化疗引起的粒细胞减少症
Low-dose (2μg/kg) granulocyte colony-stimulating factor (G-CSF) was used in 18 patients with lung cancer to observe the effect of preventing neutropenia. There were 5 cases of small cell lung cancer and 13 cases of non-small cell lung cancer. They were randomly divided into G-CSF group and control group each with 9 cases. The chemotherapy regimen was CE (carboplatin-VP16). Results The absolute granulocyte count (ANC) was less than 2.0×109/L in G-CSF group. The number of cases was 5 cases, and the duration was 3.6±3.5 days. The duration of control group was 16.8±7.1. Day, P<0.05. The number of days from the lowest ANC to normal (ANC>2.0×109/L) was 2.6±1.3 days and 8.9±5.3 days in the G-CSF and control groups, respectively (P<0. 05). In the G-CSF group, the ANC returned to normal on the 20th day after chemotherapy, and the ANC was (9.7±6.8)×109/L, so the second cycle of chemotherapy could be successfully performed on the 22nd day. The control group ANC (1.66 ± 0.8) × 109 / L (P <0.01). Thus, low-dose G-CSF can effectively prevent and treat chemotherapy-induced neutropenia in lung cancer.