核糖体大亚基上的肽链输出通道起始于肽酰转移酶中心附近 ,横穿大亚基 ,主要由 r RNA和少量蛋白质组成 ,是新生肽链离开大亚基的通道。近年研究发现这是通道的一个动态的结构 ,它不仅能够与新生肽链中的效应模体相互作用调节翻译效率 ,而且能够调节通过通道的多肽链的共翻译折叠、修饰 ,还可协助它们在细胞中定位 The ribosomal large subunit of the peptide chain output channel begins near the center of peptidyl transferase, traversing the large subunit, mainly composed of r RNA and a small amount of protein, is the nascent peptide chain leaving the large subunit channel. In recent years, it has been found that this is a dynamic structure of the channel, which not only can regulate the translation efficiency by interacting with the effector motif in the nascent peptide chain, but also can regulate co-translational folding and modification of the polypeptide chains passing through the channel, Positioning in cells