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目的研究分析长托宁和阿托品治疗急性有机磷农药中毒的治疗效果。方法选择我院在2010年10月到2011年10月收治的120例急性有机磷中毒患者。将所有患者随机分为观察组和对照组,每组各60例。观察组患者采用长托宁+绿解磷定治疗,对照组患者采用阿托品+绿解磷定治疗,对比分析两组患者的治疗效果。结果观察组中的患者的治愈率明显高于对照组,两组之间的差异具有统计学意义,P<0.05。观察组患者在用药次数、恢复时间等明显优于对照组,两组之间的差异具有统计学意义,P<0.05。结论对于急性有机磷中毒的治疗选择长托宁治疗具有起效时间短,ChE活力恢复快、并发症低、安全性好的优点,值得在临床广泛使用。
Objective To study the therapeutic effect of penehyclidine hydrochloride and atropine on acute organophosphorus pesticide poisoning. Methods A total of 120 acute organophosphate poisoning patients admitted to our hospital from October 2010 to October 2011 were selected. All patients were randomly divided into observation group and control group, 60 cases in each group. The patients in the observation group were treated with penehyclidine and metoprolol, while the patients in the control group were treated with atropine and chlorpheniramine. The therapeutic effects of the two groups were compared. Results The cure rate of patients in the observation group was significantly higher than that of the control group, the difference between the two groups was statistically significant, P <0.05. Patients in the observation group were significantly better than the control group in the frequency of medication and the recovery time, the difference between the two groups was statistically significant (P <0.05). Conclusion For the treatment of acute organophosphate poisoning, penehyclidine has the advantages of short onset time, fast recovery of ChE activity, low complication and good safety. It is worth widely used in clinic.