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目的:监测莱姆病(LD)在新疆地区的流行情况与特征,为LD的防治提供决策依据。方法:2000至2004年采用间接免疫荧光抗体法(IFA)、蛋白印迹法(WB),对业已证实的新疆自然疫源地区2167人份的血清标本进行抗LD螺旋体抗体(IgM、IgG)检测;采用IFA、WB、ELISA试验对来自21个县、市的门诊与住院患者,随机抽样1443人份血清标本进行抗LD螺旋体抗体(IgM、IgG)检测作对照;共计3610份血清标本。结果:自然疫源地2167人份血清中IFA:IgM阳性数546人、IgG阳性数223人、总阳性数769人,总阳性率为35.49%。其中471人份血清同时作WB法,其IgM、IgG阳性数均为28人,阳性率为13.49%,与对照组总阳性率20.99%比,差异有统计学意义(P<0.01)。结论:新疆自治区LD自然疫源地平均感染率明显高于国内(1.5%和8.06%)水平,各年度的抗体水平呈递增趋势,应该加强对新疆LD的监测与防治。
Objective: To monitor the prevalence and characteristics of Lyme disease (LD) in Xinjiang and to provide a basis for the decision-making of LD prevention and treatment. Methods: Serum samples of 2167 persons from confirmed natural epidemic areas in Xinjiang were detected by IFA and WB methods from 2000 to 2004. Using IFA, WB and ELISA tests, outpatients and inpatients from 21 counties and cities were randomized to 1443 serum samples for the detection of anti-LDL antibodies (IgM, IgG); 3610 serum samples were collected. Results: The serum IFA: IgM in natural foci were 546 and 223 respectively. The total positive number was 769, the total positive rate was 35.49%. Among them, 471 serum samples were simultaneously detected by WB method. The positive numbers of IgM and IgG were all 28, the positive rate was 13.49%, which was significantly higher than that of the control group (20.99%) (P <0.01). Conclusion: The average infection rates of LD natural foci in Xinjiang Autonomous Region were significantly higher than those in China (1.5% and 8.06%), and the antibody levels in all the years showed an increasing trend. Therefore, monitoring and control of LD in Xinjiang should be strengthened.