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目的探讨血浆同型半胱氨酸(homocysteine,HCY)水平与2型糖尿病患者血管并发症的相关性。方法用循环酶法测定130例血浆HCY水平,其中80例2型糖尿病患者(单纯性糖尿病组32例,48例为合并大血管或微血管并发症的糖尿病患者),50例为健康对照组。结果糖尿病患者HCY均值明显高于对照组,且合并症患者明显高于单纯性糖尿病患者,差异有统计学意义(P<0.05)。结论HCY与糖尿病血管病变密切相关,可能是其发生、发展的一个独立危险因素。
Objective To investigate the relationship between plasma homocysteine (HCY) and vascular complications in type 2 diabetic patients. Methods Cyclic HCY levels were measured in 130 patients with type 2 diabetes mellitus (80 with type 2 diabetes mellitus, 48 with diabetes or macrovascular complications) and 50 healthy controls. Results The mean HCY in diabetic patients was significantly higher than that in controls, and the patients with comorbidities were significantly higher than those in patients with simple diabetic patients (P <0.05). Conclusion HCY is closely related to diabetic vascular disease, which may be an independent risk factor for its occurrence and development.