现已证实,青光眼滤过手术失败的主要原因是手术区域纤维组织增生阻塞了滤过道,在众多的治疗或预防方法中抗代谢药氟嘧啶(Fluorouracil,5-FU)的研究令人瞻目,国内对此已有零星报道.为进一步研究和应用该药,并为其它抗纤维增殖药物的类似研究提供参照.现将5-FU在滤过术中抑制纤维组织增殖的药物作用,细胞培养、药物动力学、毒性试验、动物试验、新型药物释放系统的研究情况,以及临床应用并发症等综述如下: It has been confirmed that the main reason for the failure of glaucoma filtration surgery is that the proliferation of fibrous tissue in the operation area blocks the filtration tract. The research on anti-metabolite Fluorouracil (5-FU) is promising in many treatment or prevention methods, In order to further study and apply this medicine, and to provide references for other similar studies on anti-fibrotic drugs, the role of 5-FU in inhibiting the proliferation of fibrous tissue during filtration surgery, cell culture, Pharmacokinetics, toxicity tests, animal experiments, the new drug release system research, and clinical application of complications are summarized as follows: