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目的：探讨砷对小鼠及人体 Ｓ Ｏ Ｄ活力的影响。方法：给予小鼠灌胃染毒亚砷酸钠，观察小鼠全血及组织中 Ｓ Ｏ Ｄ活力的变化，同时对接砷人群全血中 Ｓ Ｏ Ｄ活力进行检测。结果：在急性实验中，全血及心脏中 Ｓ Ｏ Ｄ 活力中、高剂量组显著降低；肝脏低剂量组、肾脏中剂量组 Ｓ Ｏ Ｄ活力显著增高，高剂量组则显著降低。亚慢性实验中，低剂量组开始肝脏中 Ｓ Ｏ Ｄ 活力逐渐降低；全血及心脏中 Ｓ Ｏ Ｄ活力仅在高剂量组开始显著降低。人群调查可见病区病人组的 Ｓ Ｏ Ｄ 活力明显低于对照组。结论：砷可引起机体 Ｓ Ｏ Ｄ 活力发生变化，其影响主要表现为抑制作用。
Objective: To investigate the effect of arsenic on the activity of S O D in mice and human. Methods: Mice were given intragastric administration of sodium arsenite to observe the changes of S O D activity in whole blood and tissues of mice. At the same time, the activity of S O D in whole blood was measured. Results: In acute experiment, the activity of S O D in whole blood and heart was significantly lower in medium and high dose groups; the activity of S O D in medium and low dose of liver group was significantly higher than that in high dose group. In subchronic experiments, the SOD activity in the liver gradually decreased in the low-dose group, while the SOD activity in the whole blood and the heart decreased significantly only in the high-dose group. Population survey showed that patients ward S O D activity was significantly lower than the control group. Conclusion: Arsenic can cause changes in the activity of SOD, the main effect is inhibition.