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对壳聚糖膜吸附和缓释水杨酸过程的介电监测显示:伴随着吸附或释放的进行,相应膜/溶液体系的介电谱也发生规律性变化.通过对这一变化的系统分析,对介电弛豫产生的机制提出了新的看法,确认了吸附或缓释行为引起的溶液中的浓差极化是介电弛豫产生的根本原因,进而由浓差极化层电导率梯度、厚度与介电谱弛豫强度之间的理论关系解释了体系介电谱随时间等因素变化的原因.这一弛豫机制的确立,有望为建立获得吸附或释放过程体系各相的动态变化参数的理论方法、从而实现介电谱方法对药物控制释放过程的实时监测开辟一个新的途径.
Dielectric monitoring of the chitosan membrane adsorption and slow release salicylic acid process showed that the dielectric spectra of the corresponding membrane / solution systems also changed regularly with the adsorption or release. By systematically analyzing this change , Put forward a new view on the mechanism of dielectric relaxation and confirm that the concentration polarization in solution caused by adsorption or slow release behavior is the fundamental reason for the dielectric relaxation and then the conductivity of the concentration polarization layer The theoretical relationship between the gradient, the thickness and the dielectric strength of the dielectric relaxation explains the reason why the dielectric constant of the system varies with time, etc. The establishment of this relaxation mechanism is expected to establish the dynamic The theoretical method of changing the parameters, so as to realize the dielectric spectroscopy method to open up a new way for the real-time monitoring of the drug controlled release process.