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AIM:To determine the expression of L1 in pancreaticneuroendocrine tumor and to correlate it with WHO clas-sification of this tumor.METHODS:We retrospectively analyzed L1 expres-sion in 63 cases of pancreatic neuroendocrine tumor byimmunohistochemistry on paraffin sections of primarytumors or metastases.Staining was performed by per-oxidase technique with monoclonal antibody UJ127.11against human L1,All tumors were classified accordingto WHO classification as well-differentiated neuroendo-crine tumors and carcinomas or poorly-differentiatedneuroendocrine carcinomas.RESULTS:L1 was detected in 5 (7.9%) of 63 pancre-atic neuroendocrine tumors.Four (44.4%) of 9 poorly-differentiated carcinomas expressed L1,In contrast,only1 (1.9%) of 54 well-differentiated tumors or carcinomaswas positive for L1.No expression was found in Langer-hans islet cells of normal pancreatic tissue.Cross tableanalysis showed a significant association between L1 ex-pression and classification of neuroendocrine tumors ofthe pancreas(P<0,01).CONCLUSION:L1 is specifically expressed in poorly-differentiated pancreatic neuroendocrine carcinomasthat are known to have the worst prognosis.L1 might bea marker for risk prediction of patients diagnosed with pancreatic neuroendocrine carcinomas.
AIM: To determine the expression of L1 in pancreatic neuroendocrine tumor and to correlate it with WHO clas-sification of this tumor. METHODS: We retrospectively analyzed L1 expres-sion in 63 cases of pancreatic neuroendocrine tumor by immunohistochemistry on paraffin sections of primary tumors or metastases. was performed by per-oxidase technique with monoclonal antibody UJ127.11against human L1, All tumors were classified according to WHO classification as well-differentiated neuroendo-crine tumors and carcinomas or poorly-differentiated neuroendocrine carcinomas .RESULTS: L1 was detected in 5 (7.9%) of 63 well-differentiated tumors or carcinomas was positive for L1.No expression was found in Langer-hans (44.4%) of 9 poorly-differentiated carcinomas expressed L1, In contrast, only1 islet cells of normal pancreatic tissue. Cross table analysis showed a significant association between L1 ex-pression and classification of neuroendocrine tumors of the pancreas (P <0,01). CONCLUSION: L1 is specifically expressed in poorly-differentiated pancreatic neuroendocrine carcinoma are known to have the worst prognosis. L1 might be marker for risk prediction of patients diagnosed with pancreatic neuroendocrine carcinomas.