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目的 观察人参茎叶皂甙对梗阻性黄疸大鼠的心肌保护作用。方法 应用结扎Wis tar大鼠胆总管的方法制作了梗阻性黄疸的动物模型 ,80只大鼠分四个实验组 :胆总管结扎组(CBDL组 )、胆总管结扎加用腹腔注射人参皂甙组 (BDL SLG组 )、手术对照组 (OC组 )、正常对照组(NC组 )。每组 2 0只鼠 ,用电镜及光镜观察胆总管结扎术后 3、7、14、2 1d各组大鼠的心肌改变。结果 随着胆总管结扎时间的增加 ,心肌损害亦相应加重 ,电镜及光镜下心肌损害越明显 ,而CBDL SLG组的心肌改变较与其相对应的CBDL各组的心肌改变明显减轻 ,术后 7、14、2 1d时 ,两组的肌节长度、密度、线粒体体积密度及线粒体表面积密度差异显著 ,P <0 .0 1。结论 人参茎叶皂甙具有心肌保护作用 ,其作用机理为其具有生物膜保护作用
Objective To observe the cardioprotective effect of ginseng stem and leaf saponin on obstructive jaundice in rats. Methods Animal models of obstructive jaundice were established by ligation of Wiscon rat common bile duct. Eighty rats were divided into four experimental groups: common bile duct ligation group (CBDL group), common bile duct ligation plus intraperitoneal injection of ginsenoside group BDL SLG group), operation control group (OC group) and normal control group (NC group). Twenty rats in each group were used to observe the myocardial changes of rats in each group at 3, 7, 14 and 21 days after the common bile duct ligation by electron microscope and light microscope. Results With the increase of ligation time of common bile duct, myocardial damage also increased accordingly. The myocardial damage was more obvious under electron microscope and light microscope. Compared with CBDL SLG group, myocardial changes in CBDL SLG group were significantly reduced. , 14,21d, the two groups of sarcomere length, density, mitochondrial bulk density and mitochondrial surface area density difference was significant, P <0. Conclusion Ginseng stems and leaves saponin has a myocardial protective effect, its mechanism of action as a biofilm protective effect