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[目的]评价以芦笋为原料开发的功能食品速溶芦笋粉改善睡眠功效。[方法]通过60名志愿者试食实验,每日食用一次,一次两袋(24 g),连续食用60 d,进行睡眠状况评估,同时测定安全性指标及失眠相关内分泌指标,观察速溶芦笋粉对人体睡眠障碍的改善作用。[结果]速溶芦笋粉可明显增加有失眠困扰测评者有效睡眠时间,由5.1 h延长至6.1 h;缩短入睡时间,由50.4 min缩短到25.3 min;醒后再入睡时间明显减少,平均时间由46.5 h减少至19.5 h,食用前后差异显著(P<0.05),测评者对睡眠质量改善满意度较高。食用后无肝肾功能影响,具有较好的安全性。速溶芦笋粉可以降低皮质醇、去甲肾上腺素水平,提高5-羟色胺、多巴胺水平。[结论]人体试食试验表明,速溶芦笋粉有改善睡眠质量作用,安全有效,其改善睡眠作用可能与调节HPA轴或调节5-羟色胺分泌相关。
[Objective] To evaluate the efficacy of instant asparagus powder for functional foods developed from asparagus. [Method] The experiment of 60 volunteers was conducted. The daily consumption of two bags (24 g) once a day for 60 days was used to evaluate the sleep condition. At the same time, the indexes of safety and insomnia-related endocrine indexes were measured. The effects of instant asparagus On the improvement of human sleep disorders. [Result] Instant asparagus powder could significantly increase the effective sleep time of insomnia patients from 5.1 h to 6.1 h; shorten the time to fall asleep from 50.4 min to 25.3 min; the time to fall asleep after wake-up significantly decreased from 46.5 h reduced to 19.5 h, before and after eating significant differences (P <0.05), the evaluation of patients with higher satisfaction with sleep quality improvement. No liver and kidney function after eating, with good safety. Instant asparagus powder can reduce cortisol, norepinephrine levels, increased serotonin, dopamine levels. [Conclusion] The human diet test showed that instant asparagus powder had the effect of improving sleep quality and was safe and effective. The improvement of sleep function may be related to the regulation of HPA axis or the regulation of serotonin secretion.