用AtlasTM人cDNA表达分析方法分析了As2 O3 对食管鳞状上皮癌EC871 2细胞的基因表达的影响效应 .结果多数癌基因经As2 O3 诱导后表现为降调节 ,多数肿瘤抑制基因则表现为升调节 ,细胞周期调控蛋白、细胞内信号通路中促进细胞分裂的受体和因子、多个凋亡相关基因及凋亡的效应因子的表达发生改变 .因此 ,As2 O3 对食管鳞状上皮癌EC871 2细胞的效应是广泛的 ,引起多种类型基因表达改变 The effect of As2O3 on the gene expression of esophageal squamous cell carcinoma EC871 2 cells was analyzed using AtlasTM human cDNA expression analysis method. The majority of oncogenes were down-regulated by As2O3 induction, and most of the tumor suppressor genes were upregulated. , Cell cycle regulation proteins, receptors and factors that promote cell division in cell signaling pathways, expression of multiple apoptosis-related genes, and apoptosis-related effectors are altered. Therefore, As2O3 in esophageal squamous cell carcinoma EC871 2 cells The effects are extensive and cause multiple types of gene expression changes