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目的:探讨EZH2蛋白在舌鳞状细胞癌组织中的表达及其与临床病理的关系。方法:应用免疫组织化学染色法检测EZH2蛋白在52例舌鳞癌组织和12例正常舌组织标本中的表达。结合患者临床病理和随访资料,应用SPSS17.0软件分析EZH2的表达与相关临床病理参数以及患者总生存率之间的关系。结果:EZH2在舌鳞癌组织中呈高表达,与在正常组织中的表达有显著统计学差异(P<0.001)。EZH2蛋白表达与肿瘤病理学分级(P=0.033)、颈淋巴结转移(P=0.036)和局部浸润性(P=0.012)有关,而与患者的性别、年龄、肿瘤大小、临床分期无关(P>0.05)。Kaplan-Meier法分析患者的总体生存情况发现EZH2高表达组患者的总体生存率明显低于EZH2低表达组患者(P=0.028,Log-rank检验)。结论:EZH2在舌鳞状细胞癌组织中呈高表达,其表达水平与肿瘤病理学分级、颈淋巴结转移、局部浸润性及患者预后有关。
Objective: To investigate the expression of EZH2 protein in tongue squamous cell carcinoma and its relationship with clinical pathology. Methods: Immunohistochemical staining was used to detect the expression of EZH2 protein in 52 cases of tongue squamous cell carcinoma and 12 cases of normal tongue tissues. Combined with clinical pathology and follow-up data, the relationship between EZH2 expression and clinicopathological parameters and overall patient’s survival rate was analyzed by SPSS17.0 software. Results: EZH2 was highly expressed in tongue squamous cell carcinoma and significantly different from that in normal tissues (P <0.001). EZH2 protein expression was correlated with tumor pathological grade (P = 0.033), cervical lymph node metastasis (P = 0.036) and local infiltration (P = 0.012), but not with sex, age, tumor size and clinical stage 0.05). Kaplan-Meier analysis of the overall survival of patients found that patients with high expression of EZH2 overall survival was significantly lower than EZH2 low expression group patients (P = 0.028, Log-rank test). CONCLUSION: EZH2 is highly expressed in tongue squamous cell carcinoma and its expression level is related to tumor pathological grade, cervical lymph node metastasis, local infiltration and prognosis.