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应用未标记免疫酶技术(PAP法)显示94例鼻咽癌和52例慢性鼻咽炎组织切片中的癌胚抗原(CEA)。鼻咽癌的CEA阳性率为28.7％,分化差的腺癌CEA阳性率(53.8％)显著高于分化差的鳞癌(17.6％),未分化癌失去产生CEA的能力。CEA含量与癌瘤分化程度有关。分化好的鳞癌角化区域和慢性鼻咽炎中正常鳞状上皮CEA阳性反应可能是抗CEA血清与角质或前角质物质交叉反应的结果。鼻咽假复层纤毛柱状上皮CEA阳性率为35.7％(15/42),似与鼻咽的粘膜炎症轻重有关,本组轻度炎症者仅10例CEA均为阴性。本文还对鼻咽癌组织中CEA出现的生物学意义作了初步分析。
Unlabeled immunoenzyme technology (PAP) was used to show CEA in 94 cases of nasopharyngeal carcinoma and 52 cases of chronic nasopharyngitis. The positive rate of CEA in nasopharyngeal carcinoma was 28.7%. The CEA positive rate of poorly differentiated adenocarcinoma (53.8%) was significantly higher than that of poorly differentiated squamous cell carcinoma (17.6%), and the ability of undifferentiated cancer to lose CEA production. CEA content is related to the degree of cancer differentiation. The positive CEA positive response in well-differentiated squamous cell carcinoma keratoses and normal squamous epithelium in chronic nasopharyngitis may be the result of cross-reactivity of anti-CEA serum with keratin or pro-keratoses. The positive rate of CEA of nasopharyngeal pseudo-columnar columnar epithelium was 35.7% (15/42), which was related to the severity of mucosal inflammation of nasopharyngeal. Only 10 CEA cases with mild inflammation in this group were negative. This paper also makes a preliminary analysis of the biological significance of CEA in nasopharyngeal carcinoma.