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目的:探讨分析鼻咽癌外照射结合腔内近距离放疗的疗效。方法:回顾性分析1997-01-2002-10我院171例鼻咽癌患者经60Co外照射后给予鼻咽局部192Ir高剂量率近距离放疗的临床资料。结果:171例5年生存率为72.88%;Ⅰ、Ⅱ和Ⅲ期5年生存率分别为100.0%、86.75%和64.45%,P=0.000 8;外照射后鼻咽局部无残留108例,5年生存率为82.24%;残留63例,5年生存率为63.53%,P=0.026 2。鼻咽近距离剂量≥8 Gy,长期生存率影响明显;未出现软腭穿孔、鼻咽大出血、蝶骨坏死严重放疗并发症。结论:外照射后对鼻咽近距离照射,局部控制率提高,提高生存率;对鼻咽癌外照射残留近距离放疗,疗效比较肯定;增加鼻咽局部近距离剂量,对长期生存率影响明显。
Objective: To investigate the effect of external beam irradiation combined with brachytherapy in nasopharyngeal carcinoma. Methods: A retrospective analysis of 1997-01-2002-10 171 patients with nasopharyngeal carcinoma in our hospital after irradiation by 60Co nasopharyngeal 192Ir local dose of high-dose brachytherapy clinical data. Results: The 5-year survival rate of 171 patients was 72.88%; the 5-year survival rates of Ⅰ, Ⅱ and Ⅲ were 100.0%, 86.75% and 64.45%, respectively, P = 0.000 8; The annual survival rate was 82.24%. 63 cases were residual, the 5-year survival rate was 63.53%, P = 0.026 2. Nasopharyngeal close distance dose ≥ 8 Gy, long-term survival rate significantly; no soft palate perforation, nasopharyngeal hemorrhage, sphenoid necrosis severe radiotherapy complications. Conclusion: After external irradiation, nasopharyngeal close irradiation, local control rate increased, improve survival rate; Surgical treatment of nasopharyngeal carcinoma residual radiation brachytherapy, the effect is more sure; increase nasopharyngeal local short-distance dose, the impact of long-term survival rate significantly .