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对Graves′病患者 ,用放射免疫分析法 (RIA)测定了IL -6和TNF -α,用双抗体夹心ELISA法测定了IFN -γ。Graves′病患者的IL -6、TNF -α、IFN -γ水平均高于对照者。治疗后 ,IL -6水平降至正常 ,而TNF-α、IFN -γ水平仍高于对照者。提示 :IL -6水平与病情变化相平行 ,而TNF -α、IFN -γ水平仍较高。
IL-6 and TNF-α were measured by radioimmunoassay (RIA) in Graves’ disease patients and IFN-γ was measured by sandwich ELISA. Patients with Graves’ disease had higher levels of IL-6, TNF-α and IFN-γ than controls. After treatment, the levels of IL-6 dropped to normal while the levels of TNF-α and IFN-γ were still higher than those of the controls. It is suggested that the level of IL-6 is in parallel with the change of the disease, while the levels of TNF-α and IFN-γ are still high.