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本文报告存活3年以上的小儿急性白血病30例,男22例,女8例,年龄2～13岁。其中13例存活≥5年,6例已无病存活10年以上。结果表明,高危急性淋巴细胞白血病初治时,外周血白细胞数≥25×10~9/L,中枢神经系统白血病和骨髓复发是影响长期生存的危险因素。提示化疗过程中保持骨髓轻度抑制,加强前2年的化疗强度,坚持5年维持治疗及加强髓外白血病的防治是取得长期存活的关键。
This article reports the survival of more than 3 years in children with acute leukemia in 30 cases, 22 males and 8 females, aged 2 to 13 years. Of these, 13 survived ≥5 years and six had survived for more than 10 years without disease. The results showed that high-risk acute lymphoblastic leukemia at initial treatment, peripheral blood leukocyte count ≥ 25 × 10 ~ 9 / L, central nervous system leukemia and bone marrow recurrence are risk factors affecting long-term survival. Prompt chemotherapy to maintain a mild suppression of bone marrow to strengthen the intensity of the first two years of chemotherapy, adhere to 5 years of maintenance treatment and to strengthen the prevention and treatment of extramedullary leukemia is the key to long-term survival.