目的:综述巯基化合物对非金属毒物中毒解毒作用的进展.方法:通过离体细胞培养、整体动物急性实验和中毒病人的临床救治等途径观察.结果:巯基是许多蛋白和酶保持正常结构和功能的重要基团,外源性巯基化合物可以保持细胞内巯基氧化还原的正常比率和蛋白巯基的功能状态,还可通过其它机制参与机体多种功能的调节.许多实验证明,巯基化合物对农药、甲苯四氢吡咤、甲萘醌等非金属毒物中毒的解毒作用.结论:巯基化合物对某些非金属毒物中毒有保护和治疗作用. OBJECTIVE: To summarize the progress of detoxification of sulfhydryl compounds on non-metallic poison poisoning.Methods: The in vitro cell culture, whole animal acute experiment and clinical treatment of poisoned patients were observed.Results: Sulfhydryl group is the normal structure and function of many proteins and enzymes Exogenous thiol compounds can maintain the normal ratio of intracellular thiol redox and protein thiol functional status, but also through other mechanisms involved in the regulation of a variety of functions of the body.Many experiments show that the mercapto compounds on pesticides, toluene Tetrahydropyridine, Menadione and other non-metallic toxic poisoning detoxification effect.Conclusion: Thiol compounds on the protection and treatment of some non-metallic toxic poisoning.