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冠心病是绝经后妇女致死的主要原因之一,雌激素替代治疗可使冠心病的危险性减少50％。最近研究表明大剂量雌激素能抑制低密度脂蛋白(LDL)的氧化,而单核巨噬细胞对氧化LDL的过量摄取在动脉硬化的发病中起关键性作用。绝经后妇女雌激
Coronary heart disease is one of the leading causes of death in postmenopausal women, estrogen replacement therapy can reduce the risk of coronary heart disease by 50%. Recent studies have shown that high-dose estrogen can inhibit the oxidation of low-density lipoprotein (LDL), while excessive uptake of oxidized LDL by monocyte-macrophage plays a key role in the pathogenesis of atherosclerosis. Postmenopausal women estrogen