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硅片类型和多孔硅结构的多样性影响了多孔硅表面的激光解吸/离子化质谱(DIOS)(无辅助基质的激光解吸/电离飞行时间质谱(LDI-TOF-MS))数据的重复性和靶的耐储时间。本工作通过在多孔硅的表面淀积金纳米颗粒并将其作为目标靶来增强软物质分子如聚乙二醇和多肽的激光解吸/电离质谱信号。纳米金的淀积钝化了多孔硅表面的Si-H活性基团,增加了靶的耐储时间。用场发射扫描电镜表征了多孔硅淀积金纳米颗粒前后的形貌,用X射线能量色散光谱法分析金的百分含量,结果表明其含量随沉积时间的延长而增加。激光解吸/电离质谱信号的增强可能是由多孔硅及其支持的金纳米颗粒的光学和物理性质引起的,该类型的样品靶在激光解吸/电离飞行时间质谱的应用上结合了多孔硅和金纳米颗粒的双重优势。
The diversity of wafer types and porous silicon structures affects the repeatability of data on laser desorption / ionization mass spectrometry (DIOS) on porous silicon surfaces (laser desorption / ionization time-of-flight mass spectrometry without ancillary substrates (LDI-TOF-MS) Resistance of the target storage time. In this work, laser desorption / ionization mass spectrometry signals of soft substance molecules such as polyethylene glycol and polypeptide are enhanced by depositing gold nanoparticles on the surface of porous silicon and targeting them. Nano gold deposition passivates the Si-H active sites on the surface of the porous silicon, increasing the shelf life of the target. The morphology of porous silicon-deposited Au nanoparticles was characterized by field emission scanning electron microscopy. The content of gold was analyzed by X-ray energy dispersive spectrometry. The results showed that the content of Au increased with deposition time. Enhancement of laser desorption / ionization mass spectrometry signals may be caused by the optical and physical properties of porous silicon and its supported gold nanoparticles, which combines porous silicon and gold with laser desorption / ionization time of flight mass spectrometry applications The dual advantages of nanoparticles.