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目的应用基于体素的形态测量学方法(VBM)研究先天性耳聋患者的灰质和白质变化情况。资料与方法对18例先天性耳聋患者和22名健康自愿者全脑进行三维磁共振成像数据采集,应用(diffeomorphic anatom-ical registration through exponential lie algebra,DARTEL)对灰质和白质进行VBM分析。以簇体积>100个体素,且P<0.001为差异有统计学意义。结果与健康自愿者相比,耳聋患者灰质体积增大的脑区为左侧颞横回和双侧小脑(P<0.001);灰质体积减小的脑区为双侧楔回、左侧梭状回和右侧中央前回(P<0.001);白质体积减小的脑区为双侧前扣带回、左侧胼胝体、左侧舌回和右侧额中回(P<0.001)。结论先天性耳聋患者灰质和白质发生改变,反映了脑可塑性重组及患者使用手语交流导致脑结构发生的改变。
Objective To investigate the changes of gray matter and white matter in patients with congenital deafness using voxel-based morphometry (VBM). MATERIALS AND METHODS VBM analysis of gray matter and white matter was performed on whole brain of 18 patients with congenital deafness and 22 healthy volunteers by dif feomorphic anatomic-logical registration through exponential lie algebra (DARTEL). With cluster volume> 100 voxels, and P <0.001 for the difference was statistically significant. Results Compared with healthy volunteers, deafness patients had enlarged temporal regions of the left temporal gyrus and bilateral cerebellum (P <0.001). Gray matter volume decreased in the brain regions with bilateral wedges and left fusiform (P <0.001). The brain areas with reduced white matter volume were bilateral anterior cingulate gyrus, left corpus callosum, left lingual gyrus, and right middle frontal gyrus (P <0.001). Conclusions The gray matter and white matter of congenital deafness patients changed, reflecting the change of brain structure caused by brain plasticity and patients’ use of sign language communication.