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皮质醇(cortisol)是人类肾上腺皮质分泌的主要激素之一。它能影响机体的糖、脂肪、蛋白质等的代谢和水、电解质的分布,并且有抗炎和抑制免疫功能的作用。它属甾体类激素,也参与性激素的代谢。测定人体外周血和尿中的皮质醇含量及其变化能够较为精确地了解肾上腺皮质的功能状态,对皮质醇增多症的诊断有重要意义。近年来对人体皮质醇含量的测定已涉及到包括计划生育在内的广泛领域,世界卫生组织(WHO)把它列入计划生育研究用的放射免疫试剂盒之一。为此,我们研制了该试剂盒,并建立了新的放射免疫测定方法。
Cortisol is one of the major hormones secreted by the human adrenal cortex. It can affect the body’s sugar, fat, protein metabolism and water, electrolyte distribution, and anti-inflammatory and immune suppression effect. It is a steroid hormone, is also involved in the metabolism of sex hormones. Determination of human peripheral blood and urine cortisol content and its changes can more accurately understand the functional status of the adrenal cortex, the diagnosis of Cushing’s disease is of great significance. In recent years, the determination of human cortisol has been involved in a wide range of areas including family planning. The World Health Organization lists it as one of the radioimmunoassay kits for family planning research. To this end, we developed the kit and established a new radioimmunoassay method.