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目的研究中国汉族人群中miR-26a-1 rs7372209 C>T多态性与食管癌淋巴结转移危险因素关系。方法采用以医院为基础的病例-病例研究方法,采用基质辅助激光解吸电离飞行时间质谱(MALDI-TOF MS)技术分析85例有淋巴结转移的食管癌和270例无淋巴结转移的食管癌miR-26a-1 rs7372209 C>T基因多态性,计算各种基因型与食管癌淋巴结转移的发生风险及其95%可信区间。结果 miR-26a-1 rs7372209 C>T多态三种基因型CC、CT、TT在食管癌淋巴结转移组和无淋巴结转移组的频率分别为55.3%、36.5%、8.2%和48.5%、43.7%、7.8%,与携带miR-26a-1 rs7372209 CC基因型的个体相比较,miR-26a-1 rs7372209 TT等位基因型与食管癌淋巴结转移的危险因素无关。结论 miR-26a-1 rs7372209 C>T基因多态性可能与食管癌淋巴结转移无明显相关。
Objective To investigate the association of miR-26a-1 rs7372209 C> T polymorphism with the risk of lymph node metastasis in esophageal cancer in Chinese Han population. Methods 85 cases of esophageal cancer with lymph node metastasis and 270 cases of esophageal cancer without lymph node metastasis miR-26a were analyzed by matrix-assisted laser desorption / ionization time-of-flight mass spectrometry (MALDI-TOF MS) -1 rs7372209 C> T gene polymorphism was used to calculate the risk of lymph node metastasis and 95% confidence intervals of various genotypes and esophageal carcinomas. Results The frequencies of CC, CT and TT in miR-26a-1 rs7372209 C> T polymorphism were 55.3%, 36.5%, 8.2% and 48.5%, 43.7% in esophageal cancer lymph node metastasis group and non-lymph node metastasis group respectively , 7.8%. Compared with individuals carrying CC genotype of miR-26a-1 rs7372209, TT allele of miR-26a-1 rs7372209 was not associated with risk of lymph node metastasis in esophageal cancer. Conclusion The rs7372209 C> T polymorphism of miR-26a-1 may not be associated with lymph node metastasis of esophageal cancer.