镇咳作用与可待因相似但无成瘾性的新药盐酸双氧异丙嗪(dioxopromethazine),不久前在丹东制药厂研制成功。鉴定会由辽宁省卫生局、医药局主持,于1981年11月17日至19日在丹东市召开。药理试验表明,盐酸双氧异丙嗪具有镇咳作用和抗组胺作用。给小鼠、家兔、狗静脉注射5～25mg/kg,呈现中枢兴奋作用,此作用可被异巴比妥所对抗。小鼠灌胃半数致死量为50.43±3.59mg/kg。亚急性毒性试 A new drug called dioxopromethazine, a new drug with antitussive action similar to codeine but without addiction, was recently developed at Dandong Pharmaceutical Factory. Appraisal by the Liaoning Provincial Health Bureau, the Medical Bureau, held in November 1981 November 19 to 19 held in Dandong. Pharmacological tests showed that the two promethazine hydrochloride has antitussive and antihistamine effects. To mice, rabbits, dogs intravenous injection of 5 ~ 25mg / kg, showing the central excitatory effect, this effect can be antagonized by different barbiturates. Mice stomach lethal dose 50.43 ± 3.59mg / kg. Subacute toxicity test