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本实验研究常咯啉与其他抗心律失常药合并应用对电刺激家兔左心室致颤阙的影响。单用常咯啉在剂量范围1—8毫克/公斤内可提高家兔左心室电致颤阈,且剂量与阈值提高呈线性关系。实验又观察了5种抗心律失常药:利多卡因(10毫克/公斤),普鲁卡因胺(40毫克/公斤)、苯妥英钠(10毫克/公斤)、奎尼丁(10毫克/公斤)和心得宁(0.05,0.1,0.2毫克/公斤),其中除心得宁在所试剂量时对致颤阈无影响外,其他4种抗心律失常药皆能显著提高致颤阈。将常略啉的高、低两个剂量分别与一个抗心律失常药的固定剂量合并以观察阈值提高,以及由用合并药后的常咯啉剂量反应回归线与单用常咯啉的剂量反应回归线比较来估价合并效应。实验分析常咯啉2.0毫克/公斤与利多卡因5毫克/公斤合并对致颤阈的提高有相加作用;常咯啉1.3毫克/公斤与普鲁卡因胺20毫克/公斤合并也有相加作用。常咯啉20毫克/公斤与普鲁卡因胺20毫克/公斤合并有增强作用。
In this study, we investigated the effects of combination of regular pyrroline and other anti-arrhythmic agents on left ventricular fibrillation induced by electrical stimulation in rabbits. Single use of regular pyrroline in the dose range of 1-8 mg / kg can improve the rabbit left ventricular electrino-fibrillation threshold, and the dose and threshold increased linearly. Five antiarrhythmic agents were also tested: lidocaine (10 mg / kg), procainamide (40 mg / kg), phenytoin sodium (10 mg / kg), quinidine (10 mg / kg ) And heart Ning (0.05,0.1,0.2 mg / kg), in addition to heart Ning in the amount of the test did not affect the defibrillation threshold, the other four kinds of anti-arrhythmic drugs can significantly improve the threshold of fibrillation. The two high and low doses of conventional antipyretica were combined with a fixed dose of antiarrhythmic drugs to observe the threshold increase, and by the combination of regular dose of proton dose response regression curve and the single regression analysis of the reaction curve with the use of regular pyrroline Compare to evaluate the combined effect. Experimental analysis of the combination of statin 2.0 mg / kg and lidocaine 5 mg / kg has an additive effect on the improvement of the fibrillation threshold; there is also a combination of statin 1.3 mg / kg and procaine 20 mg / kg effect. The combination of 20 mg / kg of statin and 20 mg / kg of procainamide will enhance the effect.