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目的检测多囊卵巢综合征(PCOS)一级亲属的胰岛素及雄激素水平,进一步分析其胰岛素抵抗或高雄激素血症的发病情况。方法选择50例PCOS一级亲属为实验组,50例无PCOS家族史的正常健康者作为对照组,检测两组胰岛素、血脂、血糖、瘦素以及生殖激素睾酮、雄烯二酮水平情况。结果与正常对照组相比,PCOS一级亲属血脂、血糖明显高于对照组,胰岛素敏感性指数降低,胰岛素抵抗指数显著升高(P<0.05);游离睾酮、雄烯二酮与对照组差异明显,明显高于正常水平(P<0.05),血清瘦素水平与正常组间无明显差异。结论 PCOS女性一级亲属较正常健康者更易诱发胰岛素抵抗及高雄激素血症,更容易并发PCOS。
Objective To detect the levels of insulin and androgen in the first degree relatives of polycystic ovary syndrome (PCOS) and further analyze the incidence of insulin resistance or hyperandrogenism. Methods 50 cases of first-degree relatives of PCOS were selected as experimental group and 50 normal healthy controls without PCOS family history. The levels of insulin, blood lipid, blood glucose, leptin, and reproductive hormone testosterone and androstenedione were measured in two groups. Results Compared with the normal control group, the first-degree relatives of PCOS had significantly higher blood-lipid and blood glucose levels, lower insulin sensitivity index and higher insulin resistance index (P <0.05). The differences of free testosterone and androstenedione with the control group Obviously higher than the normal level (P <0.05), there was no significant difference between the serum leptin level and the normal group. Conclusions PCOS female first-degree relatives are more likely to induce insulin resistance and hyperandrogenism than normal healthy people, and are more likely to develop PCOS.