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为观察原发肾病综合征 (NS)及急性肾小球肾炎 (AGN)患儿的红细胞免疫功能变化。采用郭峰氏法对 2 8例NS(单纯性 1 6例 ,肾炎性 1 2例 )及 2 0例AGN患儿进行红细胞C3b受体花环率 (RBC C3bRR)及红细胞免疫复合物花环率 (RBC ICR)测定。结果 :( 1 )在RBC C3bRR方面 ,单纯性NS和肾炎性NS都显著低于对照组 (P <0 0 1 ) ,AGN低于对照组 (P <0 0 5) ;病例组间比较 ,单纯性NS显著低于AGN(P <0 0 1 ) ,也低于肾炎性NS(P <0 0 5)。 ( 2 )至于RBC ICR ,肾炎性NS、AGN均高于对照组和单纯性NB(P <0 0 5) ,而单纯性NS与对照组无明显差异 (P >0 0 5)。结果显示 :单纯性NS、肾炎性NS和AGN都存在不同程度的红细胞免疫功能变化 ,这些变化可能与其发病机理有关 ,红细胞免疫粘附能力降低也可能与患儿容易感染有关。
To observe the changes of erythrocyte immune function in children with primary nephrotic syndrome (NS) and acute glomerulonephritis (AGN). The RBC C3bRR and RBC ICR of erythrocyte immune complexes (RBC ICRs) of 28 NS patients (16 simple and 12 nephritis) and 20 AGN children were analyzed by Guo-Feng’s method. ). Results: (1) Compared with control group (P <0.01), AGN was lower in simple RBC C3bRR than pure NS and nephritis NS (P <0 05) Sex NS was significantly lower than AGN (P <0.01) and lower than that of nephritis (P <0.05). (2) As for RBC ICR, nephritis NS and AGN were higher than that of control group and simple NB (P <0 05), while there was no significant difference between simple NS and control group (P 0 05). The results showed that there were varying degrees of erythrocyte immune function changes in simple NS, nephritis NS and AGN. These changes may be related to its pathogenesis, and the decreased erythrocyte immune adherence may also be related to children’s susceptibility to infection.