对免疫应答性的特定抗原进行观察时,无论在实验动物还是在人类,都存在着个体差异,有的表现很高的应答性,有的不表现应答性。从种系来看,对特定抗原的免疫应答性存在着多样性。近年已证明产生这种多样性的原因决定于主要组织相容性抗原系统,人的HLA基因区。免疫应答性与HLA的相关,提示存在着特定的HLA和不平衡的Ir基因或Is基因,但需要通过家系分析阐明遗传方式及证 When observing a specific antigen that is immunologically responsive, there are individual differences both in experimental animals and humans, with some showing high responsiveness and some not exhibiting responsiveness. From the germline point of view, there is a diversity of immune responses to specific antigens. The reason for this diversity has been demonstrated in recent years is that of the major histocompatibility antigen system, the human HLA gene region. Immune responsiveness is associated with HLA, suggesting the presence of specific HLA and unbalanced Ir or Is genes, but needs to be elucidated by pedigree analysis of inheritance patterns and evidence