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作者研究了各种浓度的氯霉素溶液,在不同的PH值与不同的缓冲剂以及不同的灭菌法条件下的稳定性。作者用硼酸盐缓冲剂,在PH值为6,7,8,的溶液中,发现氯霉素的分解率以PH值为8的最大,PH值为7的次之,PH值为6的最小。这种关类不因灭菌法而异。无论是115℃高压灭菌30分钟的氯霉素溶液,或是加热至100℃煮沸30分钟的溶液都具有这种关系。不过高压灭菌法比煮沸法更易使氯霉素分解。例如0.5%氯霉素溶液,在PH值为8时,高压灭菌的分解率为22%而煮沸的分解率只有7%;在PH值为6时,高压灭菌
The authors studied the stability of various concentrations of chloramphenicol solution at different pH values with different buffers and different sterilization conditions. The authors used borate buffer in the PH value of 6,7,8, the solution, found that the decomposition rate of chloramphenicol pH to a maximum of 8, the PH value of 7 followed by a pH value of 6 Min. This type of sterilization does not vary. Neither the chloramphenicol solution autoclaved at 115 ° C for 30 minutes, nor the solution boiled at 100 ° C for 30 minutes had this relationship. However, autoclaving is easier than boiling to decompose chloramphenicol. For example, 0.5% chloramphenicol solution at a pH of 8, the autoclave decomposition rate was 22% and the boiling decomposition rate was only 7%; PH value of 6, autoclave