论文部分内容阅读
目的：检测子宫内膜异位症（endometriosis，EMS）患者腹腔液中IL-6、IL-8、IL-10含量及其临床意义。方法：剖腹探查手术中采集EMS组及对照组的腹腔液，用酶联免疫吸附法（ELISA）测细胞因子水平。EMS组中，13份测IL-6，16份测IL-8，22份测IL-10，共51份，对照组检测57份。结果：EMS组和对照组IL-6的含量分别为155．88±114．92ng／L和28．74±25．88ng／L（P＜0．01）。IL-8的含量分别为630．97±404．72ng／L和63．05±62．3ng／L（P＜0．01）。IL-10也明显高于对照组［（38．88±38．75ng／L比10．45±4．33ng／L（P＜0．01）〕。结论：EMS患者腹腔液中IL-6、IL-8及IL-10均升高，提示EMS患者的巨噬细胞活性增强，细胞因子含量增加，可干扰患者免疫调节功能。
Objective: To detect the content of IL-6, IL-8 and IL-10 in peritoneal fluid of patients with endometriosis (EMS) and its clinical significance. Methods: The abdominal cavity fluid of EMS group and control group were collected during laparotomy, and the level of cytokines was measured by enzyme - linked immunosorbent assay (ELISA). Among the EMS group, 13 were IL-6, 16 were IL-8, 22 were IL-10, totally 51, and 57 in the control group. Results: The levels of IL-6 in EMS group and control group were 155.88 ± 114.92ng / L and 28.74 ± 25.88ng / L, respectively (P <0.01). The levels of IL-8 were 630.97 ± 404.72ng / L and 63.05 ± 62.3ng / L, respectively (P <0.01). (38.88 ± 38.75ng / L vs 10.45 ± 4.33ng / L, P <0.01) .Conclusion: The levels of IL-6, IL-8 and IL-10 were elevated, suggesting that EMS patients with increased activity of macrophages, cytokine levels may interfere with immune function in patients.