本文报道系统性红斑狼疮242例的临床资料。从首发症状及临床表现分析:发热、关节痛(炎)最多见,其次为皮疹、肾脏损害及心血管与血液学改变。实验室检查以抗核因子最灵敏,LE细胞阳性率也高,且简便易行。盘状红斑、血小板减少性紫癜与雷诺氏现象等可先于SLE,其它症状数年出现,应引起警惕。本文同时对SLE的诊断与重叠综合征作了简要讨论。 This article reports 242 cases of systemic lupus erythematosus clinical data. From the initial symptoms and clinical manifestations: fever, joint pain (inflammation) the most common, followed by rash, kidney damage and cardiovascular and hematological changes. Laboratory tests to the most sensitive anti-nuclear factor, LE cell positive rate is high, and simple. Discoid erythema, thrombocytopenic purpura and Raynaud’s phenomenon can be preceded by SLE, other symptoms occur for several years, should be alert. This article also briefly discussed the diagnosis and overlap syndrome of SLE.