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目的探讨血清可溶性细胞间粘附分子(s ICAM-1)、降钙素原(PCT)、白介素-6(IL-6)及C肽水平检测在急性胰腺炎诊治中的临床意义。方法收集2013年2月-2014年10月来医院就诊的急性胰腺炎患者102例作为研究组,并给予常规对症治疗,同期收集健康志愿者80例作为健康对照组。检测患者治疗前后及健康志愿者血清s ICAM-1、PCT、IL-6及C肽水平差异。结果患者治疗前后血清s ICAM-1、PCI和IL-6水平均显著高于健康对照组,而C肽水平明显低于健康对照组,差异均有统计学意义(P<0.05)。经治疗,患者血清s ICAM-1、PCI和IL-6水平显著降低,而C肽水平明显升高,患者治疗前后上述指标水平比较差异均有统计学意义(P<0.05)。结论急性胰腺炎患者血清s ICAM-1、PCI和IL-6水平较高,而C肽水平较低。
Objective To investigate the clinical significance of detecting serum levels of s ICAM-1, PCT, IL-6 and C-peptide in the diagnosis and treatment of acute pancreatitis. Methods Totally 102 acute pancreatitis patients who visited the hospital from February 2013 to October 2014 were selected as the study group and given conventional symptomatic treatment. Meanwhile, 80 healthy volunteers were collected as the healthy control group. The levels of serum s ICAM-1, PCT, IL-6 and C peptide in patients before and after treatment and healthy volunteers were detected. Results The levels of serum s ICAM-1, PCI and IL-6 in patients before and after treatment were significantly higher than those in healthy controls and C-peptide levels were significantly lower than those in healthy controls (P <0.05). After treatment, the serum levels of s ICAM-1, PCI and IL-6 were significantly decreased, while the C-peptide levels were significantly increased in patients before and after treatment (P <0.05). Conclusion Serum s ICAM-1, PCI and IL-6 levels are higher in patients with acute pancreatitis and lower in C-peptide.