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目的比较氯吡格雷与阿司匹林治疗老年冠心病的临床疗效。方法选取2013年2月—2015年2月南京医科大学第一附属医院收治的冠心病老年患者98例,按照随机数字表法分为观察组与对照组,各49例。两组患者均给予硝酸酯类、他汀类降脂药等扩张血管常规治疗。在此基础上,观察组给予患者氯吡格雷治疗,对照组给予患者阿司匹林治疗。比较两组患者的临床疗效、治疗前后活化部分凝血活酶时间(APTT)、凝血酶原时间(PT)及血小板聚集率变化情况。结果观察组总有效率为93.9%,高于对照组的77.6%,差异有统计学意义(P<0.05)。治疗前两组患者APTT、PT、血小板聚集率比较,差异无统计学意义(P>0.05);治疗后观察组APTT、PT短于对照组,血小板聚集率低于对照组,差异有统计学意义(P<0.05)。结论氯吡格雷治疗老年冠心病患者的临床效果明显,且相关指标改善情况优于阿司匹林。
Objective To compare the clinical efficacy of clopidogrel and aspirin in the treatment of elderly patients with coronary heart disease. Methods A total of 98 elderly patients with coronary heart disease admitted to the First Affiliated Hospital of Nanjing Medical University from February 2013 to February 2015 were divided into observation group and control group according to the random number table method, with 49 cases in each group. Both groups were given nitrates, statins lipid-lowering drugs and other conventional treatment of dilation of blood vessels. On this basis, the observation group was treated with clopidogrel and the control group with aspirin. The clinical efficacy, APTT, PT and platelet aggregation rate before and after treatment were compared between the two groups. Results The total effective rate of the observation group was 93.9%, which was higher than that of the control group (77.6%), the difference was statistically significant (P <0.05). The APTT, PT, platelet aggregation rate in the two groups before treatment had no significant difference (P> 0.05). After treatment, APTT and PT in the observation group were shorter than those in the control group, the platelet aggregation rate was lower than that in the control group, the difference was statistically significant (P <0.05). Conclusion Clopidogrel treatment of elderly patients with coronary heart disease clinical effect is obvious, and the improvement of relevant indicators better than aspirin.