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目的:观察甲基强的松龙在缓解小儿哮喘急性发作中的疗效。方法:选取60例中、重度哮喘急性发作的患儿作为前瞻性研究对象。将患儿随机平均分为A、B、C三组。三组患儿在治疗上均采用吸氧、雾化吸入β2激动剂及吸入普米克令舒等基本的治疗措施,合并感染者应用抗生素。A组患儿在此基础上加用静脉注射甲基强的松龙;B组患儿在基本治疗基础上加用静脉注射地塞米松;C组不静脉应用激素治疗。观察治疗后喘息和肺部喘鸣音消失情况。结果:A组患儿无论在喘息症状消失方面,还是在肺部喘鸣音消失方面,均明显优于B组和C组,A组与B、C组疗效比较,差异均有统计学意义(P<0.01)。结论:早期静脉应用甲基强的松龙治疗中、重度哮喘急性发作,具有起效快、作用强、半衰期短及短期应用不良反应小等特点,在缓解哮喘症状方面明显优于地塞米松组和未静脉应用激素者。
Objective: To observe the effect of methylprednisolone in relieving the acute attack of pediatric asthma. Methods: Sixty children with acute exacerbation of moderate and severe asthma were selected as prospective study subjects. Children were randomly divided into A, B, C three groups. Three groups of children were treated with oxygen, inhaled β2 agonists and inhalation of pulmicort and so on and other basic treatment measures, the combined use of antibiotics in patients with infection. A group of children on this basis plus intravenous injection of methylprednisolone; B group of children on the basis of basic treatment plus intravenous dexamethasone; C group is not intravenous hormone therapy. Observe the treatment of wheezing and lung wheezing disappeared. Results: The children in group A were significantly better than those in group B and C in both the disappearance of wheezing symptoms and the disappearance of wheezing in lungs. There was significant difference in the efficacy between group A and groups B and C ( P <0.01). Conclusion: Early intravenous methylprednisolone treatment of moderate and severe acute exacerbation of asthma with fast onset, strong effect, short half-life and short-term adverse reactions, etc., in the relief of asthma symptoms were significantly better than the dexamethasone group And not intravenous hormone application.