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镁(Mg)在细胞外液中数量仅次于钠(Na)、钾(K)和钙(Ca),在细胞内是继K后第二多的阳离子。然而有关镁的病理生理作用以及对循环系统疾病预防方面的意义,迄今尚未得到足够重视。早在1957年,Ko~-bayashi就从流行病学角度提出河川水质与脑卒中的死亡率有关,并发现了饮水的硬度与循环系统疾病的关系,尤其是心源性死亡、猝死在硬水地域较少,这都提示了Mg和Ca对预防循环系统疾病具有重要作用,但二者是否有因果关系并未得出结论。直到最近,缺Mg引起高血压才在实验中得到证实,尤其是关于高血压和脑卒中,在高血压自然发病大鼠(SHR)和脑卒中易发病大鼠(SHRSP)这些常用动物模型身上证实有Mg的异常,而长时间给予含Mg食品可预防脑卒中。此外,从最近WHO心脏研究方面有关营养与循环系统疾病的研究结果来看,Mg在高血压和脑卒中方面的重要性愈来愈受到重视。
Magnesium (Mg) is second only to sodium (Na), potassium (K) and calcium (Ca) in the extracellular fluid and is the second most common cation in the cell after K. However, the pathophysiological role of magnesium and the prevention of circulatory diseases have not been given enough attention so far. As early as 1957, Ko ~ -bayashi put forward the epidemiological point of the river water quality and stroke mortality, and found that the relationship between drinking water hardness and circulatory diseases, especially cardiac death, sudden death in hard water area Few, all suggest that Mg and Ca play an important role in preventing circulatory diseases, but whether there is a causal relationship between them is not conclusive. Until recently, the lack of Mg-induced hypertension was confirmed experimentally, especially with regard to hypertension and stroke, as evidenced by these commonly used animal models of spontaneous hypertensive rats (SHR) and stroke-prone rats (SHRSP) Mg abnormalities, and for a long time to give Mg-containing foods can prevent stroke. In addition, according to the results of recent studies on nutrition and circulatory diseases in cardiac research of WHO, the importance of Mg in hypertension and stroke is getting more and more attention.