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目的:探讨成年女性系统性红斑狼疮(SLE)血清中抗黄体抗体与月经异常的相关性。方法:收集SLE患者及正常对照者的临床资料,详细记录入选研究对象的月经及生育情况,同时记录抗核抗体(ANA)等自身抗体的测定结果。采用酶联免疫吸附试验(ELISA)法检测患者血清中抗黄体抗体。结果:在入选的69例成年女性SLE患者中,26(38%)例患者抗黄体抗体阳性。而在40例健康对照者中,仅2(5%)例出现抗黄体抗体阳性。在入选的69例SLE患者中,29(42%)例患者的月经正常,40(58%)例患者出现月经异常。在40例健康对照者中,31(78%)例患者的月经正常,仅9(21%)例患者出现月经异常。有月经异常的SLE患者中抗黄体抗体的阳性率显著高于无月经异常的SLE患者(66%vs 18%,P<0.01),而在健康对照者中则未见有显著性差异。结论:SLE患者中抗黄体抗体的阳性率为38%,并可能与SLE的月经异常相关。
Objective: To investigate the relationship between anti-lutein antibody and abnormal menstruation in serum of adult female systemic lupus erythematosus (SLE). Methods: The clinical data of SLE patients and normal controls were collected. The menstrual and reproductive status of the selected subjects were recorded in detail and the results of autoantibodies such as anti-nuclear antibody (ANA) were recorded. Serum anti-lutein antibody was detected by enzyme linked immunosorbent assay (ELISA). RESULTS: Of the 69 female SLE patients who were enrolled, 26 (38%) had anti-lutein antibody positive. In 40 healthy controls, only 2 (5%) cases showed anti-lutein antibody positive. Of the 69 SLE patients selected, 29 (42%) had normal menstruation and 40 (58%) had abnormal menstruation. Among 40 healthy controls, 31 (78%) had normal menstruation, and only 9 (21%) had abnormal menstruation. The positive rate of anti-lutein antibody was significantly higher in SLE patients with menstrual abnormalities than in SLE patients without abnormal menstruation (66% vs 18%, P <0.01), but no significant difference was observed in healthy controls. Conclusion: The positive rate of anti-lutein antibody in SLE patients is 38%, and may be related to the abnormal menstrual flow of SLE.