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目的以生存分析方法探讨垂体瘤术后并发症的发生时间以及其影响因素。方法选取垂体瘤手术的患者60例。应用有乘积限法估计发生术后并发症的生存时间,运用Cox比例风险模型进行多因素分析。结果 60例患者总体生存时间达498天,年龄和垂体瘤大小对生存时间的影响具有统计学意义,平均相对危险度分别1.062和1.018。统计结果显示,年龄和垂体瘤大小是独立的危险因素。结论年龄大和垂体瘤体积较大侵犯海绵窦或破坏鞍底均会增加术后并发症发生风险。
Objective To investigate the occurrence time of postoperative complications of pituitary tumor and its influencing factors by means of survival analysis. Methods Sixty patients with pituitary tumor were selected. A product-limit method was used to estimate the survival time of postoperative complication and multivariate analysis was performed using the Cox proportional hazards model. Results The overall survival time of 60 patients was 498 days. The effects of age and size of pituitary tumor on the survival time were statistically significant with mean relative risk of 1.062 and 1.018, respectively. The statistical results show that age and pituitary tumor size are independent risk factors. Conclusions The larger age and the larger volume of pituitary tumor invading the cavernous sinus or destroying the saddle floor may increase the risk of postoperative complications.