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对人正常食管上皮的超微结构研究,在国内外均进行的较少。本文对人正常食管上皮进行了电镜观察,以便与食管癌的超微结构进行比较,进而有助于观察食管癌变上皮的特征。电镜观察人正常食管上皮共35例。11例取自手术切除的食管标本。24例利用 Olympus纤维内窥镜,距门齿30~38cm处,自正常食管粘膜取材。观察结果如下: 1.电镜下食管上皮分为基底细胞层、棘细胞层及表浅细胞层。连续的基底膜分隔开基底细胞与固有膜。自基底膜向固有膜内发出锚状原纤维(anchoring fibril)。偶见基底膜因斜切给人以基底膜中断的现象。
The ultrastructural study of human normal esophageal epithelium has been performed at home and abroad. In this paper, the normal human esophageal epithelium was observed by electron microscopy in order to compare with the ultrastructure of esophageal cancer, and it was helpful to observe the characteristics of esophageal carcinogenesis. Electron microscopy observed 35 cases of normal esophageal epithelium. Eleven cases were taken from surgically resected esophageal specimens. Twenty-four patients were treated with an Olympus fiberscope, located 30 to 38 cm from the incisors, and were obtained from normal esophageal mucosa. Observed as follows: 1. Under electron microscope, the esophageal epithelium is divided into basal cell layer, spinous cell layer and superficial cell layer. The continuous basement membrane separates the basal cells from the lamina propria. An anchoring fibril is generated from the basement membrane to the inherent membrane. Occasionally, basement membranes give rise to a disruption of the basement membrane due to chamfering.