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目的探讨人类乳头瘤病毒(HPV16、18)感染在桂西北地区鼻咽癌发生、发展中的作用和关系。方法采用荧光定量聚合酶链反应(PCR)技术检测150例鼻咽癌及50例正常健康人鼻黏膜中HPV16、18的携带情况。结果150例鼻咽癌患者中,有55例检出HPV16、18,检出率约为36.7%;50例正常健康人仅有3例检出HPV16、18,检出率约为6%;两者具有显著差异性?P<0.05)。结论在桂西北地区,HPV16、18与鼻咽癌的发生、发展具有较为密切的关系,有可能是鼻咽癌的发病原因之一。
Objective To investigate the role and relationship of human papillomavirus (HPV16,18) infection in the occurrence and development of nasopharyngeal carcinoma in northwestern Guangxi. Methods Fluorescent quantitative polymerase chain reaction (PCR) was used to detect the presence of HPV16,18 in nasal mucosa in 150 cases of nasopharyngeal carcinoma and 50 normal controls. Results Among the 150 NPC patients, HPV16,18 were detected in 55 cases and the detection rate was 36.7%. Only 3 out of 50 normal healthy subjects detected HPV16,18, the detection rate was about 6%. Two Who had significant differences? P <0.05). Conclusion In the northwestern Guangxi Province, HPV16,18 has a close relationship with the occurrence and development of nasopharyngeal carcinoma and may be one of the causes of nasopharyngeal carcinoma.