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1 氧自由基在小儿心血管疾病发病机理中的作用1.1 病毒性心肌炎发病机理尚不全清楚,过去认为,早期由病毒直接侵犯心肌细胞或导致代谢障碍,供血不足等引起疾病;后期由病毒或受损心肌作为抗原,引起自身免疫性疾病。近年研究及临床观察氧自由基(OFR)也参与心肌炎的发病过程,因发现心肌炎患儿红细胞内超氧化物歧化酶(SOD)活性普遍降低,血清脂质过氧化物(LPO)和红细胞过氧化氢溶血率明显高于正常健
The role of 1 oxygen free radicals in the pathogenesis of cardiovascular disease in children 1.1 The pathogenesis of viral myocarditis is not fully understood in the past that the early virus directly affects the cardiomyocytes or lead to metabolic disorders such as blood supply caused by insufficient blood supply; Myocardial damage as an antigen, causing autoimmune diseases. In recent years, the study and clinical observation of oxygen free radicals (OFR) are also involved in the pathogenesis of myocarditis, myocarditis in children found that erythrocyte superoxide dismutase (SOD) activity was generally lower, serum lipid peroxides (LPO) and erythrocyte peroxidation Hydrogen hemolysis rate was significantly higher than normal