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目的检测maspin和VEGF-C在子宫内膜样腺癌中的表达及与肌层浸润程度的意义。方法采用免疫组化法检测49例子宫内膜样腺癌及15例正常子宫内膜中maspin、VEGF-C的表达及与肌层浸润程度的意义。结果 (1)Maspin在子宫内膜样腺癌中表达阳性,肌层浸润深maspin阳性表达率增高,差异无统计学意义(P>0.05)。(2)VEGF-C在子宫内膜样腺癌中表达阳性,肌层浸润深度>1/2组阳性率(75.0%)高于肌层浸润深度≤1/2组(36.4%),差异具有统计学意义(P<0.05)。(3)子宫内膜样腺癌中maspin和VEGF-C呈正相关关系(P<0.05)。结论 maspin和VEGF-C表达上调可能共同促进了子宫内膜样腺癌的发生、发展、侵袭及转移,二者联合检测可能对临床诊疗、判断预后有指导意义。
Objective To detect the expression of maspin and VEGF-C in endometrioid adenocarcinoma and its significance in the degree of myometrial invasion. Methods The expressions of maspin and VEGF-C in 49 cases of endometrioid adenocarcinoma and 15 cases of normal endometrium were detected by immunohistochemistry. Results (1) Maspin positive expression in endometrial adenocarcinoma, muscular invasion deep maspin positive expression rate increased, the difference was not statistically significant (P> 0.05). (2) The positive rate of VEGF-C in endometrial adenocarcinoma was higher than that in the group of muscle invasion> 1/2 (75.0%), which was higher than that in myometrial invasion ≤ 1/2 (36.4%) Statistical significance (P <0.05). (3) There was a positive correlation between maspin and VEGF-C in endometrioid adenocarcinoma (P <0.05). Conclusion The up-regulation of maspin and VEGF-C may promote the occurrence, development, invasion and metastasis of endometrioid adenocarcinoma. The combined detection of them may have guiding significance for clinical diagnosis and prognosis.